Researchers at Georgetown Lombardi Comprehensive Cancer Center have
completed a critical step in the journey from a basic science discovery
in the lab to a potential clinical application, showing that an
experimental agent prevents tumor growth and spread in mice with
prostate cancer harboring a common chromosomal abnormality.
Published online Dec. 5 in PLOS ONE, the scientists say the
agent, YK-4-279, is the first drug targeted at the chromosomal
translocations found in about half of prostate cancer cells. These
translocations occur when two normal genes break off from a chromosome
and fuse together in a new location. This so-called ETS fusion produces
new genes that manufacture proteins, which then push prostate cancer
cells to become more aggressive and spread.
"Having a compound that works in mouse models brings us closer to early phase human clinical trials," says the study's lead investigator, Aykut Üren, MD, associate professor of molecular oncology at Georgetown Lombardi. "However, we are only mid-way through that process. We need to establish the potential side effects and figure out the best way to administer this compound in a human clinical study."
Üren and his colleagues used two prostate cancer lines growing in immunocompromised mice. "YK-4-279 was very effective against the mice with ETS fusion and was not effective against the mice without it," Üren reports. "That demonstrated to us the specificity with which the drug works, and gave us a good reason to expect a similar response in patients with ETS fusion-positive prostate cancer in future clinical trials."
The researchers also found that mice tolerated long-term treatment (6-12 weeks), and that YK-4-279 inhibited both the growth of the primary tumor and spread of the cancer to the lungs.
"Having a compound that works in mouse models brings us closer to early phase human clinical trials," says the study's lead investigator, Aykut Üren, MD, associate professor of molecular oncology at Georgetown Lombardi. "However, we are only mid-way through that process. We need to establish the potential side effects and figure out the best way to administer this compound in a human clinical study."
Üren and his colleagues used two prostate cancer lines growing in immunocompromised mice. "YK-4-279 was very effective against the mice with ETS fusion and was not effective against the mice without it," Üren reports. "That demonstrated to us the specificity with which the drug works, and gave us a good reason to expect a similar response in patients with ETS fusion-positive prostate cancer in future clinical trials."
The researchers also found that mice tolerated long-term treatment (6-12 weeks), and that YK-4-279 inhibited both the growth of the primary tumor and spread of the cancer to the lungs.
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